Phenotypes Associated with This Genotype

Genotype
MGI:2175046

• Allelic Composition: Grin1^tm1Bhk/Grin1^tm1Bhk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:57125 )

• slightly smaller than normal at birth

• weight difference persists to adulthood but the extent of the difference diminishes over time

• eventually mutants attain weights within the normal range

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:57125 )

increased startle reflex ( J:91878 )

• increased acoustic startle response

• male response is enhanced by exposure to predator odor (soiled rat bedding)

increased locomotor activity ( J:57125 )

• increased "ambulation" during habituation to a new environment

• treatment with Clozapine normalizes behavior at doses not affecting behavior of controls

stereotypic behavior ( J:57125 )

• increased

• treatment with Clozapine normalizes behavior at doses not affecting behavior of controls

abnormal social/conspecific interaction behavior ( J:57125 )

• all abnormal behaviors at least partially reversed by treatment with Clozapine

• do not sleep in contact with littermates

decreased aggression towards mice ( J:91878 )

• no fighting by either males or females

• no aggressive mounting behavior by females unlike control females

abnormal huddling behavior ( J:57125 )

• do not sleep huddled with littermates

reduced male mating frequency ( J:57125 )

♂ • males fail to copulate with wild-type females

abnormal social investigation ( J:57125 )

• reduced investigation of "intruder" animals

social withdrawal ( J:57125 )

• exhibit escape behavior, avoid social interactions

• do not sleep huddled with littermates

nervous system

decreased prepulse inhibition ( J:91878 )

• deficient prepulse inhibition

• inhibition deficiency offset in males exposed to predator odor (soiled rat bedding)

reproductive system

reduced male fertility ( J:57125 )

♂ • males fail to copulate with wild-type females

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:57125