Analysis Tools
mortality/aging
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• 80% of mice infected with vacinia virus or lymphocytic choriomeningitis virus die within 10 to 20 days unlike wild-type mice that control the infection
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• 33% of mice are moribund by 50 weeks of age with features indicating a transition to blast crisis
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growth/size/body
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• mice develop hepatosplenomegaly with spleen weights of 500 to 2000 mg
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• spleen weights of 500 to 2000 mg
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immune system
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• mice develop hepatosplenomegaly with spleen weights of 500 to 2000 mg
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• spleen weights of 500 to 2000 mg
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• in the bone marrow
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• the relative frequency of B cells is decreased in the spleen
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• the relative frequency of T cells is decreased in the spleen
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• 38.9+/-9.5 leukocytes per ul x103 compared to 6.76+/-0.55 leukocytes per ul x103 in wild-type mice
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• the frequency of granulocytes in the spleen, lymph node, peripheral blood and bone marrow is increased relative to in wild-type mice
• the frequency of granulocytes in the spleen and lymph nodes increases with age
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• mice exhibit lymphocyte and plasma cells hyperplasia in Peyer's patches and the lamina propria
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• the frequency of B cells is increased in the lymph nodes
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• the relative frequency of B cells is decreased in the spleen
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• the frequency of macrophage in the spleen, lymph node and bone marrow is increased relative to in wild-type mice
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• the frequency of plasma cells I reduced in the bone marrow while mice exhibit plasma cells hyperplasia in Peyer's patches and the lamina propria
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• following infection with lymphocytic choriomeningitis virus strain WE, mice exhibit 40% mortality, a reduction in primary and absence of secondary cytotoxic lymphocyte response, and persistence of the virus in the liver, spleen and kidney
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• lymph nodes are enlarged 5-fold and are populated by neutrophilic granulocytes
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• interferon-gamma production following stimulation with ConA is reduced 3-fold while production following stimulation with LPS is decreased more than 100-fold compared to in wild-type mice
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• 80% of mice infected with vacinia virus or lymphocytic choriomeningitis virus die within 10 to 20 days unlike wild-type mice that control the infection
• cytotoxic T lymphocyte response is reduced 3- to 10-fold following infection with vesicular stomatitis virus and vacinia virus
• following infection with lymphocytic choriomeningitis virus strain WE, mice exhibit 40% mortality, a reduction in primary and absence of secondary cytotoxic lymphocyte response, and persistence of the virus in the liver, spleen and kidney
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neoplasm
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• all mice develop hematologic neoplasia resembling chronic myelogenous leukemia
• 33% of mice are moribund by 50 weeks of age with features indicating a transition to blast crisis
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hematopoietic system
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• mice develop hepatosplenomegaly with spleen weights of 500 to 2000 mg
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• spleen weights of 500 to 2000 mg
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• erythropoiesis is increased compared to in wild-type mice
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• bone marrows exhibit hypercellularity due to an increase in mature granulocytes and their precursors compared to in wild-type mice
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• mice exhibit increased proliferation of abnormal megakaryocytes
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• in the bone marrow
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• the relative frequency of B cells is decreased in the spleen
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• the relative frequency of T cells is decreased in the spleen
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• 38.9+/-9.5 leukocytes per ul x103 compared to 6.76+/-0.55 leukocytes per ul x103 in wild-type mice
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• the frequency of granulocytes in the spleen, lymph node, peripheral blood and bone marrow is increased relative to in wild-type mice
• the frequency of granulocytes in the spleen and lymph nodes increases with age
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• mice exhibit lymphocyte and plasma cells hyperplasia in Peyer's patches and the lamina propria
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• the frequency of B cells is increased in the lymph nodes
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• the relative frequency of B cells is decreased in the spleen
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• the frequency of macrophage in the spleen, lymph node and bone marrow is increased relative to in wild-type mice
|
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• the frequency of plasma cells I reduced in the bone marrow while mice exhibit plasma cells hyperplasia in Peyer's patches and the lamina propria
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• following infection with lymphocytic choriomeningitis virus strain WE, mice exhibit 40% mortality, a reduction in primary and absence of secondary cytotoxic lymphocyte response, and persistence of the virus in the liver, spleen and kidney
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liver/biliary system
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• mice develop hepatosplenomegaly with spleen weights of 500 to 2000 mg
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| familial chronic myelocytic leukemia-like syndrome | DOID:0060761 |
OMIM:600080 |
J:36038 | |
