Phenotypes Associated with This Genotype

Genotype
MGI:2175075

• Allelic Composition: Irf8^tm1Hor/Irf8⁺
• Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:36038 )

• 9% of mice are moribund by 50 weeks of age with features indicating a transition to blast crisis

neoplasm

increased chronic myelocytic leukemia incidence ( J:36038 )

• hematological neoplasia

• 9% of mice are moribund by 50 weeks of age with features indicating a transition to blast crisis

hematopoietic system

abnormal definitive hematopoiesis ( J:36038 )

• deranged hematopoiesis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial chronic myelocytic leukemia-like syndrome		DOID:0060761	OMIM:600080	J:36038