Phenotypes Associated with This Genotype

Genotype
MGI:2175082

• Allelic Composition: Itgb6^tm1Des/Itgb6^tm1Des
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Juvenile baldness in Itgb6^tm1Des/Itgb6^tm1Des mice

respiratory system

respiratory system inflammation ( J:33139 )

• mice exhibit increased airway responsiveness to acetylcholine

abnormal lung morphology ( J:33139 )

• mononuclear cells consisting of a mixed lymphocyte infiltrate are present in the lung epithelium

• however, mice do not display any overt signs of lung infection

immune system

respiratory system inflammation ( J:33139 )

• mice exhibit increased airway responsiveness to acetylcholine

integument

alopecia ( J:33139 )

• mice fail to develop hair on the tops of their heads, the backs of their necks and the inner surface of their thighs

• however, by 20 to 30 days hair growth on the head and neck resumes

abnormal hair follicle morphology ( J:33139 )

• degenerating follicle cells are surrounded by mononuclear cells consisting of a macrophage infiltrate

decreased hair follicle number ( J:33139 )

• mixed cellular infiltration of dermis, macrophages; mixed cellular infiltration of airway walls, mixed lymphocytes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
asthma		DOID:2841	OMIM:600807	J:33139