Analysis Tools
mortality/aging
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• some mice fail to thrive and die prior to weaning
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reproductive system
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• some mice exhibit unilateral genital agenesia
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limbs/digits/tail
brachypodia
(
J:13039
)
|
• digit abnormalities are usually bilateral and asymmetric
• the right foot is often more severely affected than the left
|
oligodactyly
(
J:13039
)
|
• some mice have as few as 3 digits per foot
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polydactyly
(
J:13039
)
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• some mice have up to seven digits per foot
|
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• the tarsus displays fusion of adjacent elements and losses with all the preaxial elements missing
|
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• the hindlimbs below the knee appear twisted
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absent tibia
(
J:13039
)
renal/urinary system
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• some kidneys are horseshoe-shaped
|
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• mice that die prior to weaning exhibit distended kidney (unilateral or bilateral) and ureters
|
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• unilateral or bilateral
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absent kidney
(
J:13039
)
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• some mice display kidney agenesis
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hydroureter
(
J:13039
)
behavior/neurological
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• unlike wild-type mice, when mice fall they cannot control their rotation and do not land on their feet
|
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• mice exhibit loss of hindlimb function that is unilateral (preferentially the right hindlimb) though occassionally bilateral
• however, mice can still walk and swim albeit slower than wild-type mice
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growth/size/body
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• mice that die prior to weaning exhibit distended kidney (unilateral or bilateral) and ureters
|
skeleton
|
• the tarsus displays fusion of adjacent elements and losses with all the preaxial elements missing
|
absent tibia
(
J:13039
)
|
• reduction of presacral vertebrae
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