Phenotypes Associated with This Genotype

Genotype
MGI:2175144

• Allelic Composition: Nf1^tm1Tyj/Nf1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:18542 )

• 75% of mice develop tumors over 27 months, including lymphomas, leukemias, lung adenocarcinomas, hepatomas, fibrosarcomas, neurofibrosarcoma, and adrenal tumors

• mice develop similar types of tumors seen in patients with neurofibromatosis, but do not present any other classical features of the disease

increased adrenal gland tumor incidence ( J:18542 )

increased pheochromocytoma incidence ( J:18542 )

increased hepatoma incidence ( J:18542 )

increased leukemia incidence ( J:18542 )

• some heterozygotes developed lymphoid leukemia and myeloid leukemia

increased lymphoma incidence ( J:18542 )

increased lung adenocarcinoma incidence ( J:18542 )

increased fibrosarcoma incidence ( J:18542 )

increased neurofibrosarcoma incidence ( J:18542 )

liver/biliary system

increased hepatoma incidence ( J:18542 )

respiratory system

increased lung adenocarcinoma incidence ( J:18542 )

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:18542 )

increased pheochromocytoma incidence ( J:18542 )

nervous system

increased neurofibrosarcoma incidence ( J:18542 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	neurofibromatosis 1	DOID:0111253	OMIM:162200	J:18542