Phenotypes Associated with This Genotype

Genotype
MGI:2175151

• Allelic Composition: Nkx3-1^tm1Hha/Nkx3-1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal prostate gland anterior lobe morphology ( J:63764 )

♂ • at 10 months, heterozygotes exhibit dysplastic changes in the anterior prostate, although of reduced severity relative to homozygotes

prostate gland anterior lobe hyperplasia ( J:63764 )

♂ • at 2 months, heterozygotes exhibit a normal ductal epithelium in the anterior prostate (AP) relative to wild-type mice; however, moderate AP hyperplasia is observed at 10 months

prostate gland dorsolateral lobe hyperplasia ( J:63764 )

♂ • by 10 months, heterozygotes also exhibit epithelial hyperplasia in the dorsolateral prostate, although of reduced severity relative to homozygotes

♂ • similar to homozygotes, no hyperplasia is observed in heterozygous ventral prostatic lobes

endocrine/exocrine glands

abnormal prostate gland anterior lobe morphology ( J:63764 )

♂ • at 10 months, heterozygotes exhibit dysplastic changes in the anterior prostate, although of reduced severity relative to homozygotes

prostate gland anterior lobe hyperplasia ( J:63764 )

♂ • at 2 months, heterozygotes exhibit a normal ductal epithelium in the anterior prostate (AP) relative to wild-type mice; however, moderate AP hyperplasia is observed at 10 months

prostate gland dorsolateral lobe hyperplasia ( J:63764 )

♂ • by 10 months, heterozygotes also exhibit epithelial hyperplasia in the dorsolateral prostate, although of reduced severity relative to homozygotes

♂ • similar to homozygotes, no hyperplasia is observed in heterozygous ventral prostatic lobes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:63764