Analysis Tools
behavior/neurological
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• homozygotes are fertile; however, mutant males exhibit difficulties in forming copulatory plugs with advancing age
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endocrine/exocrine glands
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• adult homozygotes show a 15-fold reduction in mucin-producing cells and an 11-fold increase in ductal cells relative to wild-type mice
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• adult homozygotes show a significant reduction in BUG overall size and wet weight relative to wild-type mice, concomittant with a 15-fold loss of mucin cells
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• adult homozygotes often exhibit a transparent anterior prostate relative to the typically opaque wild-type gland
• as early as 4 weeks of age, the mutant anterior prostate displays a multilayered hyperplastic epithelium with relatively normal nuclear morphology
• by 12 weeks, the mutant anterior prostate epithelium exhibits dysplastic regions with variations in nuclear size and shape as well as loss of luminal space and secretory material
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• at 1 year, the mutant anterior prostate shows extensive hyperplastic epithelium with severely dysplastic focal areas but no evidence of tumor formation
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• adult homozygotes exhibit decreased ductal branching without an accompanying reduction in the number, overall size or wet weight of prostatic lobes
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• at 1 year, the mutant dorsolateral prostate shows mild hyperplasia and severe dysplasia
• however, the ventral prostate remains unaffected
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• as early as P10-P11, homozygotes show a 60%-75% reduction in ductal tip number relative to wild-type mice
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• adult homozygotes exhibit prostate epithelial dysplasia which becomes increasingly severe with advancing age
• by 12 weeks of age, the mutant anterior prostate epithelium displays dysplastic areas with variation in nuclear size and shape as well as aberrant mitotic figures
• at 6 weeks, homozygotes exhibit a 5.8-fold increase in epithelial cell proliferation in the anterior prostate
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• adult homozygotes exhibit prostate epithelial hyperplasia which becomes increasingly severe with advancing age
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• adult homozygotes show altered secretory protein production, with a new protein species and reduced levels of wild-type secretory proteins
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• adult homozygotes show a significant reduction or loss of major prostatic secretory proteins, with a 2.6-fold decrease in total protein concentration of ventral prostate secretions
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reproductive system
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• adult homozygotes show a 15-fold reduction in mucin-producing cells and an 11-fold increase in ductal cells relative to wild-type mice
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• adult homozygotes show a significant reduction in BUG overall size and wet weight relative to wild-type mice, concomittant with a 15-fold loss of mucin cells
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• adult homozygotes often exhibit a transparent anterior prostate relative to the typically opaque wild-type gland
• as early as 4 weeks of age, the mutant anterior prostate displays a multilayered hyperplastic epithelium with relatively normal nuclear morphology
• by 12 weeks, the mutant anterior prostate epithelium exhibits dysplastic regions with variations in nuclear size and shape as well as loss of luminal space and secretory material
|
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• at 1 year, the mutant anterior prostate shows extensive hyperplastic epithelium with severely dysplastic focal areas but no evidence of tumor formation
|
|
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• adult homozygotes exhibit decreased ductal branching without an accompanying reduction in the number, overall size or wet weight of prostatic lobes
|
|
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• at 1 year, the mutant dorsolateral prostate shows mild hyperplasia and severe dysplasia
• however, the ventral prostate remains unaffected
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|
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• as early as P10-P11, homozygotes show a 60%-75% reduction in ductal tip number relative to wild-type mice
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|
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• adult homozygotes exhibit prostate epithelial dysplasia which becomes increasingly severe with advancing age
• by 12 weeks of age, the mutant anterior prostate epithelium displays dysplastic areas with variation in nuclear size and shape as well as aberrant mitotic figures
• at 6 weeks, homozygotes exhibit a 5.8-fold increase in epithelial cell proliferation in the anterior prostate
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• adult homozygotes exhibit prostate epithelial hyperplasia which becomes increasingly severe with advancing age
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• adult homozygotes show altered secretory protein production, with a new protein species and reduced levels of wild-type secretory proteins
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• adult homozygotes show a significant reduction or loss of major prostatic secretory proteins, with a 2.6-fold decrease in total protein concentration of ventral prostate secretions
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neoplasm
preneoplasia
(
J:54465
)
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• at 1 year, the mutant anterior prostate shows extensive epithelial hyperplasia and severe dysplasia along with a marked increase in proliferating cells, modeling a preneoplastic condition
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| prostate cancer | DOID:10283 |
OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 |
J:54465 | |
