Phenotypes Associated with This Genotype

Genotype
MGI:2175771

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal spleen morphology ( J:53805 )

abnormal spleen red pulp morphology ( J:53805 )

• contains numerous megakaryocytes and lymphoblasts

increased spleen white pulp amount ( J:53805 )

• proliferative expansion of white pulp at 2 months of age

hematopoietic system

extramedullary hematopoiesis ( J:53805 )

• abnormal extramedullary hematopoiesis becoming more severe with age

• occurs in nonlymphoid tissue such as the liver in addition to lymphoid tissue

abnormal spleen morphology ( J:53805 )

abnormal spleen red pulp morphology ( J:53805 )

• contains numerous megakaryocytes and lymphoblasts

increased spleen white pulp amount ( J:53805 )

• proliferative expansion of white pulp at 2 months of age

cellular

abnormal cell cycle ( J:53805 )

• size of "S" phase population of MEFs in culture is increased

increased fibroblast proliferation ( J:53805 )

• MEFs in culture grow more rapidly and achieve higher densities

neoplasm

increased tumor incidence ( J:53805 )

• 69% of mice develop spontaneous tumors by 29 weeks of age whereas controls are free of tumors at 36 weeks

• average latency for tumor formation in 2 stage cancer induction is 9 weeks

increased cutaneous melanoma incidence ( J:98545 )

• 4 of 14 mice develop cutaneous melanomas within 12 months of birth

increased B cell derived lymphoma incidence ( J:53805 )

increased sarcoma incidence ( J:53805 )

increased fibrosarcoma incidence ( J:53805 )

increased hemangiosarcoma incidence ( J:53805 )

• angiosarcomas

integument

increased cutaneous melanoma incidence ( J:98545 )

• 4 of 14 mice develop cutaneous melanomas within 12 months of birth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	dysplastic nevus syndrome	DOID:10041		J:53805