Phenotypes Associated with This Genotype

Genotype
MGI:2175796

• Allelic Composition: Crebbp^tm1Sis/Crebbp⁺
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Skeletal formation defects in Crebbp^tm1Sis/Crebbp⁺ mice

growth/size/body

postnatal growth retardation ( J:42932 )

• Background Sensitivity: growth retardation is milder than in mice on a background containing BALB/c

skeleton

large anterior fontanelle ( J:42932 )

• Background Sensitivity: in 25% of mice compared to in 66% of heterozygotes on a background containing BALB/c

abnormal sternum morphology ( J:42932 )

• Background Sensitivity: at a much lower than in mice on a background containing BALB/c

xiphoid process foramen ( J:42932 )

• Background Sensitivity: in 16 of 24 mice, more frequent than in mice on a background containing BALB/c

craniofacial

large anterior fontanelle ( J:42932 )

• Background Sensitivity: in 25% of mice compared to in 66% of heterozygotes on a background containing BALB/c

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rubinstein-Taybi syndrome		DOID:1933	OMIM:180849 OMIM:610543 OMIM:613684	J:42932