Phenotypes Associated with This Genotype

Genotype
MGI:2175832

• Allelic Composition: Dsg3^bal-Pas/Dsg3^bal-Pas
• Genetic Background: 129S2.Cg-Dsg3^bal-Pas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

oral mucosa blisters ( J:42792 )

• formation of vesicles is frequent on the ventral surface of the tongue

digestive/alimentary system

oral mucosa blisters ( J:42792 )

• formation of vesicles is frequent on the ventral surface of the tongue

integument

alopecia ( J:42792 )

• large patches of hair loss over most of body at 15-18 days of age

• at 2 weeks of age, during the second hair cycle, appearance of fur is normal

• alopecia reappears around 8 weeks

premature hair loss ( J:42792 )

• hair easily plucked from follicles at 15-18 days of age

sparse hair ( J:42792 )

• hair loss evident prior to weaning

• hair loss very severe

abnormal hair shaft morphology ( J:42792 )

• hair fibers become dystrophic and disintegrate in catagen and telogen

abnormal hair follicle morphology ( J:42792 )

• separation of the inner and outer root sheaths of anagen follicles

• layer separation as early as 3 weeks in anagen hair follicles near sebaceous glands

thin epidermis stratum granulosum ( J:42792 )

• stratum granulosum is thin

blistering ( J:42792 )

• vesicles form on the foot pads and, rarely, the interfollicular epidermis

• frequently observed at the mucocutaneous junction of the eyelid and on the muzzle, particularly when exposed to a strong air flow

• separation between basal and suprabasilar cells

growth/size/body

oral mucosa blisters ( J:42792 )

• formation of vesicles is frequent on the ventral surface of the tongue

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pemphigus vulgaris		DOID:0060851	OMIM:169610	J:46865