Phenotypes Associated with This Genotype

Genotype
MGI:2175869

hm1

• Allelic Composition: Ets2^tm1Rgo/Ets2^tm1Rgo
• Genetic Background: either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * Black Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:47620 )

• death by E8.5

• rescue of embryos was achieved by aggregation with tetraploid embryos which provided functional extraembryonic tissue

embryo

decreased embryo size ( J:47620 )

abnormal extraembryonic tissue morphology ( J:47620 )

• persistent extracellular matrix

abnormal ectoplacental cone morphology ( J:47620 )

• failure of proliferation

abnormal trophoblast layer morphology ( J:47620 )

abnormal trophoblast giant cell morphology ( J:47620 )

growth/size/body

decreased embryo size ( J:47620 )

integument

increased curvature of auchene hairs ( J:47620 )

• exhibited by rescued mice

increased curvature of awl hairs ( J:47620 )

• exhibited by rescued mice

waved hair ( J:47620 )

• exhibited by rescued mice

increased curvature of guard hairs ( J:47620 )

• exhibited by rescued mice

increased curvature of zigzag hairs ( J:47620 )

• exhibited by rescued mice

abnormal hair follicle orientation ( J:47620 )

• exhibited by rescued mice

curly vibrissae ( J:47620 )

• exhibited by rescued mice