Phenotypes Associated with This Genotype

Genotype
MGI:2175873

• Allelic Composition: F9^tm1Ver/F9^tm1Ver
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Bleeding disorder of F9^tm1Ver/F9^tm1Ver mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:43590 )

♀N • unexpectedly, female mutant mice can give birth without bleeding-related complications

abnormal blood coagulation ( J:43590 )

♀

increased bleeding time ( J:43590 )

♀ • after tail clipping, mutant mice exhibit prolonged bleeding times (up to 4 hours, when experiment was terminated) in contrast to controls which stopped bleeding after 10-20 minutes

abnormal wound healing ( J:43590 )

♀ • unlike controls, trauma induces swelling of extremities and extensive hemorrhagic lesions including hematomas in mutant mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hemophilia B		DOID:12259	OMIM:306900	J:43590