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Phenotypes Associated with This Genotype
Genotype
MGI:2175903
Allelic
Composition
ApcMin/Apc+
Genetic
Background
involves: AKR/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• locally invasive tumors seen in older animals but no metastasis
• sometimes small areas of carcinomas in anemic animals only
• if mice are not anemic by 150 days of age, then tumors are not seen at 300 days of age
• visible tumors of the large and small intestine
• either polyploid, papillary or sessile adenomas

digestive/alimentary system
• bloody feces
• locally invasive tumors seen in older animals but no metastasis
• sometimes small areas of carcinomas in anemic animals only
• if mice are not anemic by 150 days of age, then tumors are not seen at 300 days of age
• visible tumors of the large and small intestine
• either polyploid, papillary or sessile adenomas

hematopoietic system
• progressive adult onset anemia beconming severe and chronic
• diagnosed in mutant mice by 60 days of age
• with few exceptions, likely the cause of lethality by 120 days of age
• moribund animals with hematocrits around 10-20%

homeostasis/metabolism

mortality/aging

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
familial adenomatous polyposis DOID:0050424 OMIM:PS175100
J:830


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory