neoplasm
• locally invasive tumors seen in older animals but no metastasis
• sometimes small areas of carcinomas in anemic animals only
• if mice are not anemic by 150 days of age, then tumors are not seen at 300 days of age
|
• visible tumors of the large and small intestine
• either polyploid, papillary or sessile adenomas
|
digestive/alimentary system
• locally invasive tumors seen in older animals but no metastasis
• sometimes small areas of carcinomas in anemic animals only
• if mice are not anemic by 150 days of age, then tumors are not seen at 300 days of age
|
• visible tumors of the large and small intestine
• either polyploid, papillary or sessile adenomas
|
hematopoietic system
• progressive adult onset anemia beconming severe and chronic
• diagnosed in mutant mice by 60 days of age
• with few exceptions, likely the cause of lethality by 120 days of age
|
• moribund animals with hematocrits around 10-20%
|
homeostasis/metabolism
mortality/aging
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
familial adenomatous polyposis | DOID:0050424 |
OMIM:PS175100 |
J:830 |