Phenotypes Associated with This Genotype

Genotype
MGI:2175907

• Allelic Composition: Apc^tm1Mmt/Apc⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Nascent intestinal polyps in Apc^tm1Mmt/Apc⁺ mice

neoplasm

increased intestinal adenoma incidence ( J:25200 , J:79668 )

• intestinal polyps are polyploid, papillary, or sessile adenoma; every polyp consists of a microadenoma covered with a normal layer of villous epithelium (J:25200)

• increase in incidence follows loss of normal Apc allele in nascent polyps (J:25200)

• numerous intestinal tumors develop in homozygotes (J:79668)

• most tumors are small; one animal developed a tumor >6 mm in diameter (J:79668)

digestive/alimentary system

increased intestinal adenoma incidence ( J:25200 , J:79668 )

• intestinal polyps are polyploid, papillary, or sessile adenoma; every polyp consists of a microadenoma covered with a normal layer of villous epithelium (J:25200)

• increase in incidence follows loss of normal Apc allele in nascent polyps (J:25200)

• numerous intestinal tumors develop in homozygotes (J:79668)

• most tumors are small; one animal developed a tumor >6 mm in diameter (J:79668)

intestine polyps ( J:79668 )

• multiple polyps develop soon after birth; all heterozygotes develop polyps by 7 weeks of age and numbers increase with age

• polyps are found from duodenum to rectum, mainly in small intestine

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial adenomatous polyposis		DOID:0050424	OMIM:PS175100	J:25200