Phenotypes Associated with This Genotype

Genotype
MGI:2175909

• Allelic Composition: Apc^tm1Rak/Apc⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Neoplastic lesions in an Apc^tm1Rak/Apc⁺ mouse

mortality/aging

premature death ( J:20443 )

• began dying around 32 weeks of age

• 70% were dead before 1 year of age

neoplasm

increased intestinal adenocarcinoma incidence ( J:20443 )

• found in the colon and in the duodenum and jejunum of the small intestine

• moderately to highly differentiated with infiltration into the muscularis mucosa, submucosa, or inner layer of the muscularis

increased intestinal adenoma incidence ( J:20443 )

• intestinal tumors were polypoid hyperplastic lesions

• benign villous or tubulovillous adenomas

increased hepatocellular carcinoma incidence ( J:20443 )

• focal lesions of the glandular epithelium of the liver seen at 1 year of age

cardiovascular system

rectal hemorrhage ( J:20443 )

• rectal bleeding in older mice

digestive/alimentary system

rectal hemorrhage ( J:20443 )

• rectal bleeding in older mice

increased intestinal adenocarcinoma incidence ( J:20443 )

• found in the colon and in the duodenum and jejunum of the small intestine

• moderately to highly differentiated with infiltration into the muscularis mucosa, submucosa, or inner layer of the muscularis

increased intestinal adenoma incidence ( J:20443 )

• intestinal tumors were polypoid hyperplastic lesions

• benign villous or tubulovillous adenomas

liver/biliary system

increased hepatocellular carcinoma incidence ( J:20443 )

• focal lesions of the glandular epithelium of the liver seen at 1 year of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial adenomatous polyposis		DOID:0050424	OMIM:PS175100	J:20443