Phenotypes Associated with This Genotype

Genotype
MGI:2176441

• Allelic Composition: Vhl^tm1Wml/Vhl^tm1Wml
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Placental histopathology of normal and Vhl^tm1Wml/Vhl^tm1Wml embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:42486 )

• death between E10.5 and E12.5, likely due to abnormal placental development

embryo

abnormal placental labyrinth vasculature morphology ( J:42486 )

• failed embryonic vasculogenesis, with hemorrhage evident by E11.5 to E12.5

• lacked embryonic endothelium and blood vessels

placenta hemorrhage ( J:42486 )

• hemorrhagic placenta

abnormal trophoblast layer morphology ( J:42486 )

• appeared normal until E9.5, but did not progress developmentally

abnormal placenta development ( J:42486 )

• evident between E9.5 and E10.5

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:42486 )

• failed embryonic vasculogenesis, with hemorrhage evident by E11.5 to E12.5

• lacked embryonic endothelium and blood vessels

placenta hemorrhage ( J:42486 )

• hemorrhagic placenta

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
von Hippel-Lindau disease		DOID:14175	OMIM:193300	J:42846 , J:88492