Phenotypes Associated with This Genotype

Genotype
MGI:2176527

• Allelic Composition: Ptpn11^tm1Rbn/Ptpn11^tm1Rbn
• Genetic Background: involves: 129 * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:35137 )

• homozygotes die prior to E10.5; at this stage, 44% of mutant embryos are resorbed

reproductive system

decreased litter size ( J:35137 )

• litter size from heterozygous breeding pairs averages 6.2 +/- 2.0 relative to 10.8 +/- 2.0 for heterozygous male x wild-type female crosses

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Noonan syndrome 1	DOID:0060578	OMIM:163950	J:35137