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Phenotypes Associated with This Genotype
Genotype
MGI:2176529
Allelic
Composition
Ptpn11tm1Rbn/Ptpn11+
Genetic
Background
involves: 129 * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn11tm1Rbn mutation (0 available); any Ptpn11 mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• heterozygotes show no significant differences in body weight, plasma insulin, glucose levels during fasting or after a glucose challenge, insulin-stimulated glucose uptake in soleus muscle and adipocytes, and insulin-inhibited lipolysis in adipocytes relative to wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT Noonan syndrome 1 DOID:0060578 OMIM:163950
J:35137


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory