Phenotypes Associated with This Genotype

Genotype
MGI:2176569

cx3

• Allelic Composition: Egfr^wa2/Egfr^wa2; Ptpn11^tm1Paw/Ptpn11⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfr^wa2 Wnt3a^vt * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Defects in the skin, lung and intestine of Egfr^wa2/Egfr^wa2 Ptpn11^tm1Paw/⁺ mice

mortality/aging

postnatal lethality, incomplete penetrance ( J:75413 )

• only 30% survive to weaning, with most dying within 7-10 days after birth

growth/size/body

cachexia ( J:75413 )

• exhibit progressive wasting

postnatal growth retardation ( J:75413 )

muscle

intestinal hypoperistalsis ( J:75413 )

• lumen of stomach and small and large bowels are filled with desquamated epithelial cells, suggesting lack of peristalsis

abnormal muscle morphology ( J:75413 )

• decrease in the size of subcutaneous muscle tissue

respiratory system

abnormal lung development ( J:75413 )

• lungs are immaturely developed with poorly inflated areas

atelectasis ( J:75413 )

thick pulmonary interalveolar septum ( J:75413 )

• increase in thickness and cell masses of the alveolar septae

abnormal breathing pattern ( J:75413 )

• display breathing difficulties

vision/eye

eyelids open at birth ( J:75413 )

adipose tissue

decreased subcutaneous adipose tissue amount ( J:75413 )

• decrease in the size of subcutaneous fat tissue

digestive/alimentary system

abnormal intestine morphology ( J:75413 )

• the muscle layer of the bowel is poorly organized and is decreased in thickness

intestinal hypoperistalsis ( J:75413 )

• lumen of stomach and small and large bowels are filled with desquamated epithelial cells, suggesting lack of peristalsis

integument

decreased subcutaneous adipose tissue amount ( J:75413 )

• decrease in the size of subcutaneous fat tissue

abnormal hair growth ( J:75413 )

• little hair outgrowth

waved hair ( J:75413 )

abnormal hair follicle morphology ( J:75413 )

abnormal hair follicle development ( J:75413 )

• poorly developed hair follicles

abnormal hair follicle orientation ( J:75413 )

• hair follicles are disordered

decreased hair follicle number ( J:75413 )

• skin contains no or few disorganized hair follicles

epidermal atrophy ( J:75413 )

• hypotrophy in the epidermis

thin epidermis ( J:75413 )

dry skin ( J:75413 )

• skin gradually becomes dry and flaky

flaky skin ( J:75413 )

• skin gradually becomes dry and flaky

abnormal skin condition ( J:75413 )

thin skin ( J:75413 )