Phenotypes Associated with This Genotype

Genotype
MGI:2176756

cn5

• Allelic Composition: Bdnf^tm3Jae/Bdnf^tm3Jae; Tg(Camk2a-cre)93Kln/0
• Genetic Background: involves: 129S4/SvJae * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

polyphagia ( J:71969 )

• food intake is 74% higher than in controls

increased aggression towards male mice ( J:71969 )

• display increased inter-male aggression

increased anxiety-related response ( J:71969 )

• mutants by 4 weeks of age become agitated and active and appear stressed when handled

• mutants continue to appear agitated after the habituation period in a novel cage, with a 40% reduction in activity after an hour of habituation compared to 72% reduction in controls

• in a light/dark exploration test, mutants take 3.6 times longer to make the first transition from the dark to the light compartment, they spend half as much time in the light zone compared with controls and only make 35% the number of dark-to-light zone transitions compared to controls

limb grasping ( J:106973 )

• hindlimb clasping

hyperactivity ( J:71969 )

• hyperactive when stressed

growth/size/body

obese ( J:71969 )

• increased body weight is seen at 8 weeks of age and by 30 weeks, males and females are 80 and 150% heavier than controls, respectively

increased body length ( J:71969 )

• 10% increase in naso-anal length compared with controls

homeostasis/metabolism

abnormal homeostasis ( J:71969 )

• abnormal starvation response in mutants as indicated by continued elevation of leptin, increased reduction in glucose levels, and attenuated NPY levels compared to controls after 48 hours of fasting

increased circulating glucose level ( J:71969 )

• glucose levels are 70% higher than in controls

increased circulating insulin level ( J:71969 )

• serum insulin levels are elevated 6-fold in obese mutants but normal in younger lean mutants

increased circulating leptin level ( J:71969 )

• serum leptin levels are elevated 15-fold in obese mutants but normal in younger lean mutants

insulin resistance ( J:71969 )

increased cholesterol level ( J:71969 )

• cholesterol levels are increased by 54% compared to controls

reproductive system

reduced female fertility ( J:71969 )

♀ • sterility in obese females but not younger lean females, indicating that sterility is secondary to the effect of obesity

nervous system

decreased brain weight ( J:106973 )

abnormal hippocampus CA2 region morphology ( J:106973 )

• decreased size of CA2 neurons

abnormal olfactory bulb morphology ( J:106973 )

• decreased size of the olfactory glomeruli