Phenotypes Associated with This Genotype

Genotype
MGI:2176762

• Allelic Composition: Nf1^tm1Cbr/Nf1^tm1Cbr
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal discrimination learning ( J:68489 )

• mice exhibit impaired contextual discrimination; during first two days of training, mutants do not discriminate between a chamber in which they receive a mild shock and a chamber in which they do not, however after 3 days of training, begin to discriminate between the chambers

abnormal spatial learning ( J:68489 )

• in a probe trial, mutants search randomly rather than selectively, and spend significantly less time searching for the platform in the training quadrant than wild-type

• additional training alleviates the learning deficits

impaired coordination ( J:68489 )

• mice fall off a rotating rod sooner than wild-type, however swimming speed, ambulance, exploratory behavior, and muscular strength are normal

neoplasm

neoplasm ( J:68489 )

N • mice do not have an increase in predisposition for tumor formation

nervous system

nervous system phenotype ( J:68489 )

N • mice do not exhibit gross or microscopic abnormalities in the brain, including no astrogliosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neurofibromatosis 1		DOID:0111253	OMIM:162200	J:68489