Phenotypes for Brca1 Tg(MMTV-cre)4Mam Trp53 MGI:2176786 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Brca1^tm1Cxd/Brca1^tm2Cxd Trp53^tm1Brd/Trp53⁺ Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Cxd mutation (1 available); any Brca1 mutation (114 available)
Brca1^tm2Cxd mutation (3 available); any Brca1 mutation (114 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:54533 )

• by 6-8 months of age, 8 of 11 females developed mammary gland tumors that exhibited several distinct histopathologies

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:54533 )

• by 6-8 months of age, 8 of 11 females developed mammary gland tumors that exhibited several distinct histopathologies

integument

increased mammary gland tumor incidence ( J:54533 )

• by 6-8 months of age, 8 of 11 females developed mammary gland tumors that exhibited several distinct histopathologies

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
breast cancer	DOID:1612	OMIM:114480	J:54533
hereditary breast ovarian cancer syndrome	DOID:5683		J:54533

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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