behavior/neurological
• shorter latency to enter a dark chamber 24 hours after foot shock training relative to controls
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• significantly impaired performance in a rotorod test
• no improvement in performance over time
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nervous system
• Gm2 ganglioside accumulates in the brain at 4 months
• Ga2 ganglioside shows slight accumulations in the brain at 4 months
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• pronounced ganglioside accumulations in the hypothalamic nuclei at 5 months
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• pronounced ganglioside accumulations in the amygdala at 5 months
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• pronounced ganglioside accumulations in the entorhinal cortex at 5 months
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• ganglioside accumulations in large pyramidal neurons in the middle layer of the cerebral cortex at 5 months
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• pronounced ganglioside accumulations in the piriform area at 5 months
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• ganglioside storage at 5 months
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• ganglioside storage in glial cells at 5 months
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• ganglioside storage at 5 months
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• ganglioside storage in glial cells at 5 months
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
GM2 gangliosidosis, AB variant | DOID:4795 |
OMIM:272750 |
J:41950 |