Phenotypes for Dmd Dtna MGI:2176892 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dmd^mdx/Y Dtna^tm1Jrs/Dtna^tm1Jrs
Genetic Background	involves: 129X1/SvJ * C57BL/10ScSn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^mdx mutation (31 available); any Dmd mutation (154 available)
Dtna^tm1Jrs mutation (1 available); any Dtna mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:59675 )

• life span is 8-10 months

muscle

cardiomyopathy ( J:59675 )

• develop moderate to severe cardiomyopathy

dystrophic muscle ( J:59675 )

• exhibit a more severe dystrophy than single Dmd^mdx mutant mice, but not as severe as that of double mutant Utrn^tm1Jrs and Dmd ^mdx mice or triple mutant Utrn^tm1Jrs, Dtna^tm1Jrs, and Dmd^mdx mice

cardiovascular system

cardiomyopathy ( J:59675 )

• develop moderate to severe cardiomyopathy

nervous system

abnormal neuromuscular synapse morphology ( J:60776 )

• at 2-4 months of age, synapses are broken into discrete boutons and acetylcholine receptors are patchily distributed within the boutons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Duchenne muscular dystrophy		DOID:11723	OMIM:310200	J:59675

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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