Phenotypes Associated with This Genotype

Genotype
MGI:2176972

• Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal fear/anxiety-related behavior ( J:57315 )

• impaired stress response in Porsolt forced-swim test; mice show normal immobility scores in an initial test, but do not show an increased response in a 24-hour restest

decreased anxiety-related response ( J:57315 )

• in a light-dark crossing task test, mice exhibit a reduced latentcy in entering an aversive bright compartment and spent more time there

• in a zero-maze test, mice demonstrated an increased number of entries into the averse open segment and spent more time there

growth/size/body

decreased body size ( J:57315 )

decreased body weight ( J:57315 )

• mice are 70+/-3% of the weight of control mice at 6-14 weeks of age

decreased body length ( J:57315 )

• mice are 82+/-0.4% of the length of control mice at 6-14 weeks of age

skeleton

decreased bone mineral density ( J:57315 )

• bone density is reduced in the skull and pelvis bones

osteoporosis ( J:57315 )

adipose tissue

abnormal adipose tissue distribution ( J:57315 )

• a displacement of fat tissue towards the head and neck from the rest of the body is apparent

• mice are not obese

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:57315 )

N • the morphology of the adrenal glands is similar to controls

N • levels of adrenaline and noradrenaline in the adrenal glands is similar to controls

homeostasis/metabolism

increased circulating glucocorticoid level ( J:57315 )

• morning levels of circulating glucocorticoids are elevated

• normal circadian rhythm is maintained

decreased circulating adrenocorticotropin level ( J:57315 )

• plasma levels of ACTH are moderately reduced

increased adrenocorticotropin level ( J:57315 )

• in the anterior pituitary, an increase in the level of ACTH and its transcript levels are seen

nervous system

hypersecretion of corticotropin-releasing hormone ( J:57315 )

• elevation of CRH peptide levels in the paraventricular nucleus of the hypothalamus (PVN)

• no change in the level of vasopression (AVP)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary hyperaldosteronism		DOID:446	OMIM:605635 OMIM:613677	J:57315