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Phenotypes Associated with This Genotype
Genotype
MGI:2177138
Allelic
Composition		 Gba1tm1Nsb/Gba1tm1Nsb
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gba1tm1Nsb mutation (2 available); any Gba1 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

behavior/neurological
abnormal food intake ( J:1100 )
• decreased feeding

growth/size/body
decreased birth weight ( J:1100 )
• underweight, evident at birth

hematopoietic system
abnormal macrophage morphology ( J:1100 )
• macrophages in liver, bone marrow, spleen, and brain show lysosomal lipid accumulation

homeostasis/metabolism

immune system
abnormal macrophage morphology ( J:1100 )
• macrophages in liver, bone marrow, spleen, and brain show lysosomal lipid accumulation

respiratory system
abnormal respiration ( J:1100 )
• respire abnormally from birth

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Gaucher's disease type II DOID:0110958 OMIM:230900
 J:1100

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory