About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2177138
Allelic
Composition		 Gba1tm1Nsb/Gba1tm1Nsb
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gba1tm1Nsb mutation (2 available); any Gba1 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

behavior/neurological
abnormal food intake ( J:1100 )
• decreased feeding

growth/size/body
decreased birth weight ( J:1100 )
• underweight, evident at birth

hematopoietic system
abnormal macrophage morphology ( J:1100 )
• macrophages in liver, bone marrow, spleen, and brain show lysosomal lipid accumulation

homeostasis/metabolism

immune system
abnormal macrophage morphology ( J:1100 )
• macrophages in liver, bone marrow, spleen, and brain show lysosomal lipid accumulation

respiratory system
abnormal respiration ( J:1100 )
• respire abnormally from birth

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Gaucher's disease type II DOID:0110958 OMIM:230900
 J:1100

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory