Phenotypes Associated with This Genotype

Genotype
MGI:2177237

• Allelic Composition: Brca2^tm1Arge/Brca2^tm2Arge; Wap^tm1(cre)Arge/Wap⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:70564 )

• T₅₀ for tumor-free survival is approximately 17 months of age

• mammary tumors occur after long latency of at least 13 months of age

• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none

• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:70564 )

• mammary tumors occur after long latency of at least 13 months of age

• T₅₀ for tumor-free survival is approximately 17 months of age

• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none

• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass

integument

increased mammary adenocarcinoma incidence ( J:70564 )

• mammary tumors occur after long latency of at least 13 months of age

• T₅₀ for tumor-free survival is approximately 17 months of age

• at the end of the 20 month observation period, 20 of 26 animals developed mammary tumors; control animals developed none

• tumor pathology corresponded to two characteristic types, solid carcinoma and adenoacanthoma, with a mixture of the two types frequently appearing in the same tumor mass

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:70564