Phenotypes Associated with This Genotype

Genotype
MGI:2177545

• Allelic Composition: Cftr^tm2Hgu/Cftr^tm2Hgu
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:74740 )

• focal hypertrophy of goblet cells, however do not observe distension of crypts in the small intestine or intestinal blockage

abnormal digestive system physiology ( J:74740 )

• defect in chloride ion transport in the jejunum but not the caecum

respiratory system

abnormal respiratory system physiology ( J:74740 )

• defect in chloride ion transport in the nose, with baseline nasal biolelectrics significantly raised and a reduced response to a low chloride gradient

craniofacial

craniofacial phenotype ( J:74740 )

N • teeth are normal in color

reproductive system

reproductive system phenotype ( J:74740 )

N • males and females are fertile

cellular

abnormal intestinal goblet cell morphology ( J:74740 )

• focal hypertrophy of goblet cells, however do not observe distension of crypts in the small intestine or intestinal blockage

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cystic fibrosis		DOID:1485	OMIM:219700	J:74740