Phenotypes Associated with This Genotype

Genotype
MGI:2177637

• Allelic Composition: Tfam^tm1Lrsn/Tfam^tm1Lrsn; Tg(Myhca-cre)1Lrsn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:61372 )

• animals surviving past neonatal stage survive for several months; variable penetrance speculated to be the result of a modifying gene

neonatal lethality, incomplete penetrance ( J:61372 )

• 75% of animals die as neonates

cardiovascular system

dilated heart atrium ( J:61372 )

increased heart weight ( J:61372 )

dilated heart left ventricle ( J:61372 )

dilated heart right ventricle ( J:61372 )

cellular

abnormal respiratory electron transport chain ( J:61372 )

• respiratory chain dysfunction in heart; variable penetrance speculated to be the result of a modifying gene

growth/size/body

increased heart weight ( J:61372 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Kearns-Sayre syndrome		DOID:12934	OMIM:530000	J:61372