Analysis Tools
growth/size/body
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• heart weight to body weight ratio is increased
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• in 12-week-old spontaneous cardiac hypertrophy occurs in the absence of provocative stimulation
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• commonly associated with gastrointestinal bleeding
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mortality/aging
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• some homozygous animals suffered acute blood loss and crisis which lead to premature death
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• significant loss of homozygous pups up to three weeks of age due to hemorrhage
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cardiovascular system
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• hypoxia-induced retinal neovascularization is significantly elevated as measure by numbers of vascular glomeruli at P17
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• significantly elevated numbers of vessels per square millimeter of tumors, from injected cells, when compared with wild-type controls
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• blood-vessel infiltration of matrigel implants impregnated with VEGF is significantly elevated
• in the presence of VEGF, the total number of vessel sprouts in aortic rings embedded in Matrigel is significantly higher compared to wild-type
• however, no increase in vessel density is seen on scruff skin
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• heart weight to body weight ratio is increased
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• in 12-week-old spontaneous cardiac hypertrophy occurs in the absence of provocative stimulation
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• left ventricle weight to body weight ratio is increased by 4 weeks of age
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hemorrhage
(
J:52262
)
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• some homozygous embryos and newborn pups displayed hemorrhage in the skin, in petechiae and in purpura, and appeared anemic
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• in some homozygous newborn pups which die before weaning and in many of the surviving homozygous adult mice
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• a significantly impaired contractile response to infusion of the inotropic agent Dobutamine
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• diastolic relaxation is impaired (dP/dt min and tau (Glantz) are significantly increased)
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• 12-week-old mice have reduced systolic function compared to wild-type littermates
• left ventricular peak systolic pressure is significantly decreased 7 days after pressure overload by transverse aortic constriction surgery (TAC) compared to wild-type
• left ventricular peak systolic pressure is decreased in 12-week-old mice
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• left ventricular end-diastolic pressure is significantly increased 7 days after pressure overload by transverse aortic constriction surgery (TAC) compared to wild-type
• the maximal change in pressure per unit time is significantly decreased 7 days after pressure overload by TAC surgery compared to wild-type
• minimal change in pressure per unit time is significantly increased 7 days after pressure overload by TAC surgery compared to wild-type
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• heart rate is significantly decreased 7 days after pressure overload by transverse aortic constriction surgery (TAC) compared to wild-type
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• impairment of systolic and diastolic function after transverse aortic constriction is more severe than in wild-type controls
• cardiac tissue exhibits marked round cell infiltration 7 days after transverse aortic constriction surgery
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hematopoietic system
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• commonly associated with gastrointestinal bleeding
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• found in animals with splenomegaly
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• in 8-12-week-old mice
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• in 8-12-week-old mice
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• in 8-12-week-old mice
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• the monocyte count is dramatically increased in peripheral blood
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• in 8-12-week-old mice
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• peritoneal macrophages express significantly more Tnf and Il1b
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• peritoneal macrophages migrate less efficiently
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• reduced formation of thrombi in Shwartzman-like reaction, an experimental model of hemorrhagic vasculitis induced by subcutaneous injection of LPS followed 24 h later by an injection of TNF-alpha in the same place
• platelet isolated from homozygous mice did not aggregate after ADP-induced activation in vitro
• platelet isolated from homozygous mice shows reduced clot retraction and greatly reduced fibrinogen uptake in vitro
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reproductive system
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• 9.5% of the embryos carried by homozygous mothers were found dead in utero at E14 and E17
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• compromised survival of embryos in homozygous mother as a result of placental defects and intrauterine hemorrhage
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• litter sizes of homozygous female were reduced significantly compared to wild-type
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embryo
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• within affected placentae of homozygous pregnant females, trophoblastic cells sometimes invaded the labyrinthine part of the placenta
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• thickened cell layers in the labyrinth layer in approximately 25% of placentae of homozygous pregnant females which were associated with dead embryos
• within affected placentae, the space between endothelial layers was reduced with evidence of increased necrosis
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pale placenta
(
J:52262
)
digestive/alimentary system
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• in some homozygous newborn pups which die before weaning and in many of the surviving homozygous adult mice
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immune system
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• commonly associated with gastrointestinal bleeding
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• the monocyte count is dramatically increased in peripheral blood
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• peritoneal macrophages express significantly more Tnf and Il1b
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• peritoneal macrophages migrate less efficiently
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• cardiac tissue exhibits marked round cell infiltration 7 days after transverse aortic constriction surgery
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dermatitis
(
J:52262
)
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• ulcerative dermatitis in some homozygous animals undergoing crisis
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homeostasis/metabolism
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• impairment of systolic and diastolic function after transverse aortic constriction is more severe than in wild-type controls
• cardiac tissue exhibits marked round cell infiltration 7 days after transverse aortic constriction surgery
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• reduced formation of thrombi in Shwartzman-like reaction, an experimental model of hemorrhagic vasculitis induced by subcutaneous injection of LPS followed 24 h later by an injection of TNF-alpha in the same place
• platelet isolated from homozygous mice did not aggregate after ADP-induced activation in vitro
• platelet isolated from homozygous mice shows reduced clot retraction and greatly reduced fibrinogen uptake in vitro
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• impaired hemostasis as evidenced by failure to arrest bleeding within 10 minutes following tail resection
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renal/urinary system
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• enlarged glomeruli and dilated and necrotic proximal tubules containing proteinaceous deposits are found secondary to the excessive bleeding
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liver/biliary system
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• centrilobular necrosis of the liver are found secondary to the excessive bleeding
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vision/eye
| N |
• the patterns of neovascularization in P7 retinas isolated from wild-type or homozygous mutant mice showed no obvious differences
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• hypoxia-induced retinal neovascularization is significantly elevated as measure by numbers of vascular glomeruli at P17
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neoplasm
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• significantly elevated numbers of vessels per square millimeter of tumors, from injected cells, when compared with wild-type controls
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• tumor size is enhanced significantly when injected with murine melanoma (B16F0) or lung carcinoma (CMT19T) cells
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cellular
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• endothelial cells showed background levels of adhesion and no migration on vitronectin
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• endothelial cells showed background levels of adhesion and no migration on vitronectin
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• peritoneal macrophages migrate less efficiently
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muscle
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• a significantly impaired contractile response to infusion of the inotropic agent Dobutamine
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• diastolic relaxation is impaired (dP/dt min and tau (Glantz) are significantly increased)
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• cardiac tissue exhibits marked round cell infiltration 7 days after transverse aortic constriction surgery
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integument
dermatitis
(
J:52262
)
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• ulcerative dermatitis in some homozygous animals undergoing crisis
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• petechiae are observed around the mouth, indicating bleeding under the epidermis
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| platelet-type bleeding disorder 16 | DOID:0060691 |
OMIM:187800 |
J:52262 | |
