Phenotypes for Gpnmb Tyrp1 MGI:2178287 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Gpnmb^R150X/Gpnmb^R150X Tyrp1^isa/Tyrp1^isa
Genetic Background	DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpnmb^R150X mutation (4 available); any Gpnmb mutation (43 available)
Tyrp1^isa mutation (3 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

retina ganglion cell degeneration ( J:54013 )

• loss of retinal ganglion cells

optic nerve atrophy ( J:54013 )

abnormal iris pigment epithelium ( J:54013 )

• atrophy

abnormal iris stroma morphology ( J:54013 )

• atrophy

pigmentation

abnormal iris pigment epithelium ( J:54013 )

• atrophy

nervous system

retina ganglion cell degeneration ( J:54013 )

• loss of retinal ganglion cells

optic nerve atrophy ( J:54013 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pigment dispersion syndrome		DOID:0060680	OMIM:600510	J:54013

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24