Phenotypes for Gpnmb Tyrp1 MGI:2178287 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gpnmb^R150X/Gpnmb^R150X Tyrp1^isa/Tyrp1^isa
Genetic Background	DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpnmb^R150X mutation (4 available); any Gpnmb mutation (43 available)
Tyrp1^isa mutation (3 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

retina ganglion cell degeneration ( J:54013 )

• loss of retinal ganglion cells

optic nerve atrophy ( J:54013 )

abnormal iris pigment epithelium ( J:54013 )

• atrophy

abnormal iris stroma morphology ( J:54013 )

• atrophy

pigmentation

abnormal iris pigment epithelium ( J:54013 )

• atrophy

nervous system

retina ganglion cell degeneration ( J:54013 )

• loss of retinal ganglion cells

optic nerve atrophy ( J:54013 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pigment dispersion syndrome		DOID:0060680	OMIM:600510	J:54013

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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