Phenotypes Associated with This Genotype

Genotype
MGI:2179614

hm1

• Allelic Composition: Relb^{Tg(H2-K1/GH1)106Bri}/Relb^{Tg(H2-K1/GH1)106Bri}
• Genetic Background: C57BL/6-Relb^{Tg(H2-K1/GH1)106Bri}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:76450 )

• mice that survive to weaning die within several months

preweaning lethality, incomplete penetrance ( J:76450 )

• fewer than expected mice survived to weaning (12% compared to the expected 25%)

immune system

decreased T cell proliferation ( J:76450 )

absent thymus medulla ( J:23081 , J:76450 )

• the medulla is almost completely absent (J:23081)

• the medulla is almost completely absent (J:76450)

enlarged spleen ( J:76450 )

• spleen is enlarged (3- to 10-fold larger than in wild-type mice) and unusually firm

increased granulocyte number ( J:23081 , J:76450 )

• 23% of total spleen compared to 0.5% in wild-type mice (J:76450)

decreased B cell number ( J:76450 )

decreased pre-B cell number ( J:76450 )

decreased T cell number ( J:76450 )

• 18% of spleen cells compared to 36% in wild-type mice

• however, the total number of T cells is normal

increased macrophage cell number ( J:23081 , J:76450 )

• 13% to 18% of total spleen compared to 3% to 5% in wild-type mice (J:76450)

abnormal Peyer's patch morphology ( J:76450 )

• Peyer's patch and lymph nodes are extremely difficult to find

abnormal lymph node morphology ( J:76450 )

• Peyer's patch and lymph nodes are extremely difficult to find

abnormal antigen presentation ( J:23081 )

• antigen-presenting function is impaired

increased inflammatory response ( J:23081 , J:76450 )

• mice exhibit severe inflammatory syndrome with mixed granylocyte/monocyte infiltrate in the lung, liver and other tissues (J:23081)

• inflammatory infiltrate is present in the epididymis, pancreas, skeletal muscle and cardiac muscle (J:76450)

liver inflammation ( J:76450 )

glomerulonephritis ( J:76450 )

• in older mice

lung inflammation ( J:76450 )

• infiltrate accumulates in the lung without exudates or pneumonia

skin inflammation ( J:76450 )

• mice exhibit inflammation in the skin of the ear, tail and periorbital regions

growth/size/body

decreased body size ( J:76450 )

• at weaning mice are often smaller than wild-type mice

cachexia ( J:76450 )

• all mice that survive past weaning spontaneously develop wasting syndrome

enlarged spleen ( J:76450 )

• spleen is enlarged (3- to 10-fold larger than in wild-type mice) and unusually firm

respiratory system

lung inflammation ( J:76450 )

• infiltrate accumulates in the lung without exudates or pneumonia

abnormal lung morphology ( J:76450 )

• lungs are mottled

liver/biliary system

liver inflammation ( J:76450 )

liver fibrosis ( J:76450 )

pale liver ( J:76450 )

renal/urinary system

glomerulonephritis ( J:76450 )

• in older mice

homeostasis/metabolism

skin edema ( J:76450 )

• skin on the tail and eyes becomes edematous

hematopoietic system

decreased T cell proliferation ( J:76450 )

absent thymus medulla ( J:23081 , J:76450 )

• the medulla is almost completely absent (J:23081)

• the medulla is almost completely absent (J:76450)

enlarged spleen ( J:76450 )

• spleen is enlarged (3- to 10-fold larger than in wild-type mice) and unusually firm

increased granulocyte number ( J:23081 , J:76450 )

• 23% of total spleen compared to 0.5% in wild-type mice (J:76450)

decreased B cell number ( J:76450 )

decreased pre-B cell number ( J:76450 )

decreased T cell number ( J:76450 )

• 18% of spleen cells compared to 36% in wild-type mice

• however, the total number of T cells is normal

increased macrophage cell number ( J:23081 , J:76450 )

• 13% to 18% of total spleen compared to 3% to 5% in wild-type mice (J:76450)

integument

skin edema ( J:76450 )

• skin on the tail and eyes becomes edematous

skin inflammation ( J:76450 )

• mice exhibit inflammation in the skin of the ear, tail and periorbital regions

ruffled hair ( J:76450 )

• fur becomes ruffled

hyperkeratosis ( J:76450 )

• in the skin of the ears

endocrine/exocrine glands

absent thymus medulla ( J:23081 , J:76450 )

• the medulla is almost completely absent (J:23081)

• the medulla is almost completely absent (J:76450)

cellular

decreased T cell proliferation ( J:76450 )