Analysis Tools
hematopoietic system
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• only 42% of CD4 T cells produce high levels of Ifng compared to wild-type
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• splenic NK cells from mutants produce less Ifng in response to Il-12 or Il-18 than NK cells from wild-type
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immune system
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• only 42% of CD4 T cells produce high levels of Ifng compared to wild-type
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• splenic NK cells from mutants produce less Ifng in response to Il-12 or Il-18 than NK cells from wild-type
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• increased amount of TGFb is found in bronchial alveolar lavage (BAL) fluid compared to wild-type
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• increased amounts of Il-4 and Il-13 are found in BAL fluid; Il-5 levels are high in mutants and do not increase with allergen challenge as wild-type levels do
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• increased amount of TNFa is found in bronchial alveolar lavage (BAL) fluid compared to wild-type
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respiratory system
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• mice show an increase in thickness of subbasement collagen layer of the airways, with an increased numbers of bronchial myofibroblast
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• 4-5 week old homozygous mice exhibit airway hyperresponsiveness (AHR) to methacholine challenge, in the absence of prior immunologic sensitization; mice are more responsive without allergen challenge than wild-type mice following antigen challenge
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homeostasis/metabolism
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• increased amount of TGFb is found in bronchial alveolar lavage (BAL) fluid compared to wild-type
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• increased amounts of Il-4 and Il-13 are found in BAL fluid; Il-5 levels are high in mutants and do not increase with allergen challenge as wild-type levels do
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• increased amount of TNFa is found in bronchial alveolar lavage (BAL) fluid compared to wild-type
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| asthma | DOID:2841 |
OMIM:600807 |
J:73832 | |
