Phenotypes Associated with This Genotype

Genotype
MGI:2181627

• Allelic Composition: Klf1^tm1Sho/Klf1^tm1Sho
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:25651 )

• mice die by E16

hematopoietic system

anemia ( J:25651 )

abnormal erythrocyte morphology ( J:25651 )

• fetal red blood cells are small and irregularly shaped

abnormal erythropoiesis ( J:25651 )

• erythroid maturation is defective

abnormal embryonic erythrocyte morphology ( J:25651 )

• the number of nucleated fetal erythroblasts is increased compared to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
beta thalassemia		DOID:12241	OMIM:613985	J:25651