Analysis Tools
mortality/aging
|
• 50% mortality by 40 weeks of age
|
growth/size/body
|
• smaller size persists through adulthood
|
|
• 20% growth reduction in males and 18% reduction in females from birth to 45 days of age
|
|
• usually found in mice dying after 40 weeks of age
|
neoplasm
|
• mice dying after 40 weeks of age usually have tumors that are not thymic lymphomas
|
|
• found in all mice dying before 40 weeks
• diverse cell types involved
• spongy tumors with a high proportion of cells undergoing apoptosis
|
immune system
|
• occasional increase in thymocyte size
|
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• lymph node T cells are primarily at early stages of development
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• occurs at random
|
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• randomly observed increases in single positive T cells
|
small thymus
(
J:69726
)
|
• 10% reduction in thymocytes
• 30-50% reduction in thymocytes expressing alpha and beta T cell receptors or CD3
|
|
• found in all mice dying before 40 weeks
• diverse cell types involved
• spongy tumors with a high proportion of cells undergoing apoptosis
|
|
• usually found in mice dying after 40 weeks of age
|
small spleen
(
J:69726
)
|
• in mice under 40 weeks of age
|
cellular
 |
• loss of spermatids
|
|
|
• degenerating spermatocytes
|
|
• 3 fold increase in radiation induced chromosomal aberrations
|
|
• increased sensitivity of thymocytes and splenocytes to ionizing radiation
|
 |
• disrupted
• lack of maturing follicles and oocytes
|
reproductive system
|
|
• tubules disrupted
|
|
|
• poorly developed
|
|
|
• disrupted
• lack of maturing follicles and oocytes
|
|
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• disrupted spermatogenesis
|
|
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• loss of spermatids
|
|
|
• degenerating spermatocytes
|
nervous system
| N |
• no gross neuronal degeneration at time points between 2 and 16 months of age
|
|
• survival of Purkinje cells in culture less than 60% of controls at 4 days and about 40% at 10 day
• survival of cultured cells improves if cultured with cerebellar astroglial cells
• develop simpler dendritic arboritization with reduced secondary branching
• nitroxide free radicals improve survival and arborization
|
endocrine/exocrine glands
small thymus
(
J:69726
)
|
• 10% reduction in thymocytes
• 30-50% reduction in thymocytes expressing alpha and beta T cell receptors or CD3
|
|
• found in all mice dying before 40 weeks
• diverse cell types involved
• spongy tumors with a high proportion of cells undergoing apoptosis
|
|
|
• tubules disrupted
|
|
|
• poorly developed
|
hematopoietic system
small thymus
(
J:69726
)
|
• 10% reduction in thymocytes
• 30-50% reduction in thymocytes expressing alpha and beta T cell receptors or CD3
|
|
• found in all mice dying before 40 weeks
• diverse cell types involved
• spongy tumors with a high proportion of cells undergoing apoptosis
|
|
• usually found in mice dying after 40 weeks of age
|
|
• lymph node T cells are primarily at early stages of development
|
|
• occurs at random
|
|
• randomly observed increases in single positive T cells
|
small spleen
(
J:69726
)
|
• in mice under 40 weeks of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| ataxia telangiectasia | DOID:12704 |
OMIM:208900 |
J:69726 | |
