Phenotypes for Smad4 MGI:2182801 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Smad4^tm1Mmt/Smad4⁺
Genetic Background	B6.129S2-Smad4^tm1Mmt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4^tm1Mmt mutation (0 available); any Smad4 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

duodenum polyps ( J:59214 )

• mutants older than 1 year develop inflammatory polyps in the duodenum

gastric polyps ( J:59214 )

• mutants older than 1 year develop inflammatory polyps in the glandular stomach, often in the pyloric region

• polyps show Smad4 loss of heterozygosity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
juvenile polyposis syndrome		DOID:0050787	OMIM:174900	J:59214

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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