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Phenotypes Associated with This Genotype
Genotype
MGI:2182801
Allelic
Composition		 Smad4tm1Mmt/Smad4+
Genetic
Background		 B6.129S2-Smad4tm1Mmt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4tm1Mmt mutation (0 available); any Smad4 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
duodenum polyps ( J:59214 )
• mutants older than 1 year develop inflammatory polyps in the duodenum
gastric polyps ( J:59214 )
• mutants older than 1 year develop inflammatory polyps in the glandular stomach, often in the pyloric region
• polyps show Smad4 loss of heterozygosity

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
juvenile polyposis syndrome DOID:0050787 OMIM:174900
 J:59214

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory