Phenotypes Associated with This Genotype

Genotype
MGI:2183034

• Allelic Composition: Csf3r^tm1Eur/Csf3r^tm1Eur
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal hematopoietic system morphology/development ( J:51444 )

• primitive hematopoietic stem cells become reduced in numbers by 4-5 weeks of age

increased bone marrow cell number ( J:48503 )

• elevated numbers of early stage neutrophiles are found in bone marrow

abnormal myeloblast morphology/development ( J:48503 )

• hyperproliferative response of myeloid precursors to G-CSF

abnormal neutrophil differentiation ( J:48503 )

• elevated numbers of early stage neutrophiles are found in bone marrow

decreased neutrophil cell number ( J:48503 )

• by 60% (30-40% in heterozygotes)

• daily injections of G-CSF (250ug/kg) bring neutrophile numbers back to normal by day 2, 3-4X normal by day 7, 10X normal by day 21

immune system

abnormal neutrophil differentiation ( J:48503 )

• elevated numbers of early stage neutrophiles are found in bone marrow

decreased neutrophil cell number ( J:48503 )

• by 60% (30-40% in heterozygotes)

• daily injections of G-CSF (250ug/kg) bring neutrophile numbers back to normal by day 2, 3-4X normal by day 7, 10X normal by day 21

cellular

abnormal neutrophil differentiation ( J:48503 )

• elevated numbers of early stage neutrophiles are found in bone marrow

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary neutrophilia		DOID:0090120	OMIM:162830	J:48503