Phenotypes Associated with This Genotype

Genotype
MGI:2183380

hm1

• Allelic Composition: Msh6^tm1Rak/Msh6^tm1Rak
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:44428 )

• 40% dead by 9 months of age

• 65% dead by 12 months of age

• 92% dead by 15 months of age

• median survival time was 10 months

neoplasm

increased tumor incidence ( J:44428 )

• 92% of mice develop a spectrum of tumors, but predominantly GI tumors and T- and B-cell lymphomas

increased gastrointestinal tumor incidence ( J:44428 )

increased lymphoma incidence ( J:44428 )

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:44428 )