Phenotypes Associated with This Genotype

Genotype
MGI:2384175

• Allelic Composition: Trpv3^Nh/Trpv3⁺
• Genetic Background: involves: DS

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

dermatitis ( J:42153 )

• age of onset is noted as 8 weeks affecting 5-10% of mice housed under conventional conditions

• by 24 weeks of age, all mice are affected when housed under conventional conditions

• mice housed under a pathogen free barrier system do not display this phenotype

increased susceptibility to bacterial infection ( J:42153 )

• dermatitis is caused by an increased susceptibility to Staphylococcus aureus

integument

dermatitis ( J:42153 )

• age of onset is noted as 8 weeks affecting 5-10% of mice housed under conventional conditions

• by 24 weeks of age, all mice are affected when housed under conventional conditions

• mice housed under a pathogen free barrier system do not display this phenotype

abnormal hair growth ( J:42153 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:42153