Phenotypes Associated with This Genotype

Genotype
MGI:2385750

• Allelic Composition: Tg(APOB)11Rub/0; Tg(UcpDta)1Kz/0
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:73122 )

• on a high-fat, Western diet by 10 weeks of age, males are significantly heavier than Tg(APOB)11Rub and wild-type controls

homeostasis/metabolism

abnormal glucose homeostasis ( J:73122 )

increased circulating insulin level ( J:73122 )

• males on a Western diet exhibit increased fasting plasma insulin levels

• however, fasting plasma glucose and free fatty acid levels do not vary from controls

insulin resistance ( J:73122 )

• males, but not females, are insulin resistant; males are impaired in their ability to clear exogenously administered glucose

abnormal lipid homeostasis ( J:73122 )

• males display a human-like dyslipidemia

• males exhibit increased synthesis and secretion of very low density lipoprotein (VLDL) triglycerides

• males exhibit increased apolipoprotein B (apoB) secretion rates

decreased circulating HDL cholesterol level ( J:73122 )

• HDL cholesterol is significantly reduced relative to Tg(APOB)11Rub mice

increased circulating cholesterol level ( J:73122 )

• males on a Western diet exhibit increased fasting plasma total cholesterol concentrations

increased circulating LDL cholesterol level ( J:73122 )

• LDL cholesterol is increased relative to Tg(APOB)11Rub mice

increased circulating triglyceride level ( J:73122 )

• males on a Western diet exhibit increased fasting plasma triglyceride concentrations

• IDL/LDL triglyceride levels are increased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:78211