mortality/aging
• surviving mice dead by 22 days of age
|
• incomplete penetrance
|
behavior/neurological
abnormal gait
(
J:76608
)
growth/size/body
• exhibit a retarded but steady growth until 1.5 weeks, but fail to gain weight after 2-3 weeks
|
skeleton
osteoporosis
(
J:76608
)
adipose tissue
• complete absence of body fat, including subcutaneous fat
|
cellular
• seen in MEFs
|
integument
• severe dilation of hair follicles
|
• excessive epidermal hyperkeratosis
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
photosensitive trichothiodystrophy | DOID:2960 | J:76608 | ||
xeroderma pigmentosum group A | DOID:0110843 |
OMIM:278700 |
J:76608 |