Phenotypes Associated with This Genotype

Genotype
MGI:2388265

• Allelic Composition: Adrb1^tm1Bkk/Adrb1^tm1Bkk; Adrb2^tm1Bkk/Adrb2^tm1Bkk; Adrb3^tm1Lowl/Adrb3^tm1Lowl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:79309 )

• obesity attributable to increased fat mass

abnormal brown adipose tissue morphology ( J:79309 )

• interscapular brown adipose tissue (BAT) enlarged and pale

• BAT contained large cells with unilocular triglyceride deposits

increased brown fat cell size ( J:79309 )

increased interscapular fat pad weight ( J:79309 )

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:79309 )

N • normal thyroid hormone levels

growth/size/body

increased body weight ( J:79309 )

obese ( J:79309 )

• on regular Chow diet, mildly obese by 20 weeks; increased obesity on high fat diet (58% of kcal from fat)

• normal food intake and normal physical activity on both normal and high fat diets were observed, however

homeostasis/metabolism

impaired adaptive thermogenesis ( J:79309 )

• normal body temperature under conventional housing conditions, but exposure to cold (22^oC) produced rapid decline in core body temperature

• failure of diet-induced thermogenesis

increased circulating leptin level ( J:79309 )

• increased leptin levels

decreased oxygen consumption ( J:79309 )

• reduced metabolic rate, measured by O₂ consumption

• isoproterenol exposure failed to increase O₂ consumption

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:79309