Phenotypes Associated with This Genotype

Genotype
MGI:2447459

• Allelic Composition: Nf2^tm1Tyj/Nf2⁺
• Genetic Background: either: (involves: 129S2/SvPas * 129S4/SvJae * C57BL/6) or (involves: 129S2/SvPas * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

neoplasm ( J:47282 )

N • schwannomas, meningiomas, or ependymomas were not detected

increased lymphoma incidence ( J:47282 )

increased malignant tumor incidence ( J:47282 )

• increased incidence of highly metastatic tumors, including osteosarcoma, lymphoma, lung adenocarcinomas, hepatocellular carcinoma and fibrosarcoma

• osteosarcoma frequency was higher in females and the frequency of fibrosarcomas was higher in males

increased carcinoma incidence ( J:47282 )

increased lung adenocarcinoma incidence ( J:47282 )

increased sarcoma incidence ( J:47282 )

increased fibrosarcoma incidence ( J:47282 )

increased osteosarcoma incidence ( J:47282 )

respiratory system

increased lung adenocarcinoma incidence ( J:47282 )

skeleton

increased osteosarcoma incidence ( J:47282 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	familial meningioma	DOID:4586		J:47282