Phenotypes Associated with This Genotype

Genotype
MGI:2448998

• Allelic Composition: Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk
• Genetic Background: B6.129S4-Fcgr2b^tm1Ttk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:64152 )

• death by 9 months, with evidence of clear distress, including: hunched posture, edema, dehydration

behavior/neurological

hunched posture ( J:64152 )

abnormal seizure response to electrical stimulation ( J:169028 )

• mice exhibit lower electroconvulsive threshold to generalized seizure compared with wild-type mice

maximal tonic hindlimb extension seizures ( J:169028 )

• in response to transcorneal electrical stimulation

tonic-clonic seizures ( J:169028 )

• in response to transcorneal electrical stimulation

digestive/alimentary system

salivary gland inflammation ( J:64152 )

• pathological examination at 8 months of age showed inflammatory cell infiltration in the salivary gland

endocrine/exocrine glands

salivary gland inflammation ( J:64152 )

• pathological examination at 8 months of age showed inflammatory cell infiltration in the salivary gland

pancreas inflammation ( J:64152 )

• pathological examination at 8 months of age showed inflammatory cell infiltration in the pancreas

growth/size/body

decreased body weight ( J:64152 )

• reduced weight, evident with signs of distress near death

enlarged spleen ( J:64152 )

hematopoietic system

enlarged spleen ( J:64152 )

anemia ( J:64152 )

• evident at 8 months of age

increased immunoglobulin level ( J:64152 )

• high serum titers of antinuclear antibodies (ANA)

homeostasis/metabolism

dehydration ( J:64152 )

edema ( J:64152 )

increased urine protein level ( J:64152 )

• evident beginning at 5 months of age in 40% of mice and in 90% of mice at 9 months of age

immune system

enlarged spleen ( J:64152 )

increased immunoglobulin level ( J:64152 )

• high serum titers of antinuclear antibodies (ANA)

enlarged lymph nodes ( J:64152 )

abnormal hypersensitivity reaction ( J:64152 )

• pathological examination at 8 months of age showed severe multiorgan inflammatory disease

increased inflammatory response ( J:64152 )

• pathological examination at 8 months of age showed severe multiorgan inflammatory disease with inflammatory cell infiltration in the lungs, kidneys, salivary glands, pancreas, liver, tongue, and muscle

salivary gland inflammation ( J:64152 )

• pathological examination at 8 months of age showed inflammatory cell infiltration in the salivary gland

pancreas inflammation ( J:64152 )

• pathological examination at 8 months of age showed inflammatory cell infiltration in the pancreas

liver inflammation ( J:64152 )

• pathological examination at 8 months of age showed inflammatory cell infiltration in the liver

kidney inflammation ( J:64152 )

• pathological examination at 8 months of age showed inflammatory cell infiltration in the kidney

glomerulonephritis ( J:64152 )

• evident at 8 months

lung inflammation ( J:64152 )

• pathological examination at 8 months of age showed inflammatory cell infiltration in the lung

renal/urinary system

increased urine protein level ( J:64152 )

• evident beginning at 5 months of age in 40% of mice and in 90% of mice at 9 months of age

kidney inflammation ( J:64152 )

• pathological examination at 8 months of age showed inflammatory cell infiltration in the kidney

glomerulonephritis ( J:64152 )

• evident at 8 months

respiratory system

lung inflammation ( J:64152 )

• pathological examination at 8 months of age showed inflammatory cell infiltration in the lung

cardiovascular system

vascular inflammation ( J:64152 )

• pathological examination at 8 months of age showed systemic vasculitis

liver/biliary system

liver inflammation ( J:64152 )

• pathological examination at 8 months of age showed inflammatory cell infiltration in the liver

nervous system

abnormal seizure response to electrical stimulation ( J:169028 )

• mice exhibit lower electroconvulsive threshold to generalized seizure compared with wild-type mice

maximal tonic hindlimb extension seizures ( J:169028 )

• in response to transcorneal electrical stimulation

tonic-clonic seizures ( J:169028 )

• in response to transcorneal electrical stimulation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:64152