Phenotypes Associated with This Genotype

Genotype
MGI:2449556

• Allelic Composition: Cybb^tm1Din/Y
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

cardiac hypertrophy ( J:115652 )

♂ • Angiotensin II infusion causes a 5% cardiac mass change as compared to a 20% change in controls

decreased body weight ( J:115614 )

♂ • body weight is slightly but significantly reduced at 10-12 weeks of age

immune system

abnormal immune system physiology ( J:22868 )

♂

abnormal neutrophil physiology ( J:22868 )

♂ • neutrophils lacked respiratory burst activity

abnormal macrophage physiology ( J:22868 )

♂ • macrophages lacked respiratory burst activity

increased inflammatory response ( J:22868 )

♂ • dysregulated inflammatory response; increased numbers of peritoneal exudate neutrophils in chemical peritonitis induced by thioglycollate

increased susceptibility to infection ( J:22868 )

♂ • increased frequency of spontaneously occurring infections

increased susceptibility to bacterial infection ( J:22868 )

♂ • increased susceptibility to S. aureus infection and A. fumigatus infection

cardiovascular system

abnormal aorta tunica media morphology ( J:115614 )

♂ • medial area of the aorta is unaffected by angiotensin II infusion whereas it increases in controls

cardiac hypertrophy ( J:115652 )

♂ • Angiotensin II infusion causes a 5% cardiac mass change as compared to a 20% change in controls

decreased systemic arterial blood pressure ( J:115614 )

♂ • baseline blood pressure is significantly reduced at 10-12 weeks of age

decreased systemic arterial systolic blood pressure ( J:115652 )

♂ • lower baseline systolic pressure

hematopoietic system

abnormal neutrophil physiology ( J:22868 )

♂ • neutrophils lacked respiratory burst activity

abnormal macrophage physiology ( J:22868 )

♂ • macrophages lacked respiratory burst activity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic granulomatous disease		DOID:3265	OMIM:PS306400	J:22868