Phenotypes Associated with This Genotype

Genotype
MGI:2450635

• Allelic Composition: Hbb^d3th/Hbb^d3th
• Genetic Background: involves: C57BL/6 * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:7209 )

• although born at normal ratios, 37% die before weaning

• survival from weaning to 5 months of age is normal

hematopoietic system

abnormal erythrocyte morphology ( J:7209 )

low mean erythrocyte cell number ( J:7209 )

• RBC counts reduced to around 10.2 x 10⁶/mm³

decreased hematocrit ( J:7209 )

• around 37%

abnormal hemoglobin ( J:7209 )

• reduced hemoglobin

• beta major hemoglobin is absent

• beta minor hemoglobin is elevated to about 24.6%

abnormal hemoglobin content ( J:7209 )

• beta/alpha hemoglobin ratio is reduced

decreased mean corpuscular hemoglobin ( J:7209 )

decreased mean corpuscular volume ( J:7209 )

anisocytosis ( J:7209 )

• variable size of RBCs

anisopoikilocytosis ( J:7209 )

hyperchromasia ( J:7209 )

• increased numbers of nucleated RBCs

microcytosis ( J:7209 )

• large numbers of microcytes and cellular debris

poikilocytosis ( J:7209 )

reticulocytosis ( J:7209 )

reproductive system

decreased litter size ( J:7209 )

• reduced size of litters produced by females

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
beta thalassemia		DOID:12241	OMIM:613985	J:7209