Phenotypes Associated with This Genotype

Genotype
MGI:2651379

• Allelic Composition: Itgb2^tm1Bay/Itgb2^tm1Bay
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased leukocyte cell number ( J:13599 , J:32126 )

• Background Sensitivity: increased total leukocyte counts however less elevated than on the PL/J background (J:32126)

increased granulocyte number ( J:13599 )

increased lymphocyte cell number ( J:13599 )

decreased inflammatory response ( J:13599 )

• decreased inflammatory response to i.p. injection of thioglycollate showing decreased migration of neutrophils into the peritoneal cavity

• delayed rejection of cardiac transplants

hematopoietic system

increased leukocyte cell number ( J:13599 , J:32126 )

• Background Sensitivity: increased total leukocyte counts however less elevated than on the PL/J background (J:32126)

increased granulocyte number ( J:13599 )

increased lymphocyte cell number ( J:13599 )

integument

integument phenotype ( J:32126 )

N • Background Sensitivity: did not develop progressive dermatitis in the 129S7/SvEvBrd background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
leukocyte adhesion deficiency 1		DOID:0110910	OMIM:116920	J:13599