Phenotypes Associated with This Genotype

Genotype
MGI:2651564

hm1

• Allelic Composition: Lifr^tm1Cgre/Lifr^tm1Cgre
• Genetic Background: either: (involves: 129P2/OlaHsd * CBA) or (involves: 129P2/OlaHsd * MF1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:82048 )

• mice became moribound and died within 1 day of birth

growth/size/body

decreased body weight ( J:82048 )

• body weight reduced 20% relative to heterozygous and wild-type littermates

nervous system

decreased motor neuron number ( J:82048 )

• greater than 35% loss of facial motor neurons

• 40% loss of spinal motor neurons

• 50% loss of neurons in nucleus ambiguus