Phenotypes Associated with This Genotype

Genotype
MGI:2651807

• Allelic Composition: Lpl^tm1Bres/Lpl⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:30062 )

• 42% reduction in the VLDL fractional catabolic rate

• a vitamin A fat tolerance test used to asses dietary fat (chylomicron) clearance indicates a delay in the clearance of chylomicrons and VLDL

increased circulating cholesterol level ( J:30062 )

• 10-30% modest elevation

increased circulating VLDL cholesterol level ( J:30062 )

• increase in cholesterol is in the VLDL fraction

increased circulating triglyceride level ( J:30062 )

• both in the fed and fasted state, triglyceride levels are 52-126% higher

increased circulating VLDL triglyceride level ( J:30062 )

• increase in triglycerides is in the VLDL fraction

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial lipoprotein lipase deficiency		DOID:14118	OMIM:238600	J:30062